SB 204990

CAS No. 154566-12-8

SB 204990( —— )

Catalog No. M23668 CAS No. 154566-12-8

SB 204990 is an effective and specific ATP citrate lyase enzyme inhibitor.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 84 In Stock
10MG 147 In Stock
25MG 291 In Stock
50MG 534 In Stock
100MG 763 In Stock
200MG Get Quote In Stock
500MG Get Quote In Stock
1G Get Quote In Stock

Biological Information

  • Product Name
    SB 204990
  • Note
    Research use only, not for human use.
  • Brief Description
    SB 204990 is an effective and specific ATP citrate lyase enzyme inhibitor.
  • Description
    SB 204990 is an effective and specific ATP citrate lyase enzyme inhibitor.
  • In Vitro
    SB204990 (SB) is a specific inhibitor of ACLY enzyme. SB204990 treatment leads to a decrease in cytosolic Ac-CoA level and is thus expected to decrease acetylated and active β-catenin levels.
  • In Vivo
    SB 204990, when administered orally to rats, is absorbed into the systemic circulation. When administered in the diet (0.05-0.25%, w/w) for 1 week, SB 204990 causes a dose-related decrease in plasma cholesterol (by up to 46%) and triglyceride levels (by up to 80%) in rats. SB 204990 (25 mg/kg per day) also decreases plasma cholesterol levels (by up to 23%) and triglyceride levels (by up to 38%) in the dog, preferentially decreasing low-density lipoprotein compared with high-density lipoprotein cholesterol levels.
  • Synonyms
    ——
  • Pathway
    Endocrinology/Hormones
  • Target
    ATPase
  • Recptor
    ACLY
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    154566-12-8
  • Formula Weight
    389.27
  • Molecular Formula
    C18H22Cl2O5
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:100 mg/mL (256.89 mM);H2O:10 mg/mL (25.69 mM; Need ultrasonic)
  • SMILES
    O[C@](CC(O)=O)(C[C@@H](CCCCCCc(ccc(Cl)c1)c1Cl)O1)C1=O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Shares BH, et al. Active mitochondria support osteogenic differentiation by stimulating β-catenin acetylation. J Biol Chem. 2018 Oct 12;293(41):16019-16027.
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