
SB 204990
CAS No. 154566-12-8
SB 204990( —— )
Catalog No. M23668 CAS No. 154566-12-8
SB 204990 is an effective and specific ATP citrate lyase enzyme inhibitor.
Purity : >98% (HPLC)






Size | Price / USD | Stock | Quantity |
5MG | 84 | In Stock |
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10MG | 147 | In Stock |
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25MG | 291 | In Stock |
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50MG | 534 | In Stock |
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100MG | 763 | In Stock |
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200MG | Get Quote | In Stock |
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500MG | Get Quote | In Stock |
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1G | Get Quote | In Stock |
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Biological Information
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Product NameSB 204990
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NoteResearch use only, not for human use.
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Brief DescriptionSB 204990 is an effective and specific ATP citrate lyase enzyme inhibitor.
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DescriptionSB 204990 is an effective and specific ATP citrate lyase enzyme inhibitor.
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In VitroSB204990 (SB) is a specific inhibitor of ACLY enzyme. SB204990 treatment leads to a decrease in cytosolic Ac-CoA level and is thus expected to decrease acetylated and active β-catenin levels.
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In VivoSB 204990, when administered orally to rats, is absorbed into the systemic circulation. When administered in the diet (0.05-0.25%, w/w) for 1 week, SB 204990 causes a dose-related decrease in plasma cholesterol (by up to 46%) and triglyceride levels (by up to 80%) in rats. SB 204990 (25 mg/kg per day) also decreases plasma cholesterol levels (by up to 23%) and triglyceride levels (by up to 38%) in the dog, preferentially decreasing low-density lipoprotein compared with high-density lipoprotein cholesterol levels.
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Synonyms——
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PathwayEndocrinology/Hormones
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TargetATPase
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RecptorACLY
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Research Area——
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Indication——
Chemical Information
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CAS Number154566-12-8
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Formula Weight389.27
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Molecular FormulaC18H22Cl2O5
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Purity>98% (HPLC)
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SolubilityDMSO:100 mg/mL (256.89 mM);H2O:10 mg/mL (25.69 mM; Need ultrasonic)
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SMILESO[C@](CC(O)=O)(C[C@@H](CCCCCCc(ccc(Cl)c1)c1Cl)O1)C1=O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Shares BH, et al. Active mitochondria support osteogenic differentiation by stimulating β-catenin acetylation. J Biol Chem. 2018 Oct 12;293(41):16019-16027.
molnova catalog



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